Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold: SAR of the Biphenyl Moiety Stefano Sainas, Marta Giorgis, Paola Circosta, Valentina Gaidano, Davide Bonanni,... read more →
Introduction: Interest in developmental immunotoxicology has been stimulated following suggestions over recent years that xenobiotics may be capable of influencing the human immune system in such a way as to render... read more →
Aim of the study: Validation and application of an analytical qPCR method under GLP in a safety study by quantifi-cation of a viral vaccine in 13 different tissues for assessment of... read more →
Aim of the study: Biopharmaceutical products may contain host cell derived protein impurities at low levels. A method for the detection of antibodies to HCP in human serum of patients... read more →
Aim of the study: Ex vivo drug detection in tissue sections by MALDI TOF-TOF and MALDI Imaging Mass Spectrometry and correlation with Pharmacokinetic (PK) data in order to investigate and verify... read more →
Aim of the study: In order to support ELISA results, the aim was to find a sensitive and reliable method for milk allergen detections in bakery. Validation of the method... read more →
Aim of the study: Detection and quantification of a variety of viral nucleic acids, in order to spot the presence of possible contaminations in production batches, as quality control. Analyte: RNA and... read more →
Aim of the study: Globe artichoke, besides its role in human nutrition, represents a promising source of biopharmaceuticals. Many of its properties rely on specific metabolites known to be triggered by... read more →
Aim of the study: Binding of therapeutic antibodies to proteins other than the target can lead to altered pharmacokinetics and off-site toxicity. We assessed whether a therapeutic antibody could non-specifically bind... read more →
Aim of the study: A comparison between two maize flours was chosen as a model to verify proteomics capability in detecting unexpected differences between near-isogenic lines. Analyte: Maize seedlings. Methodology: Protein expression in... read more →