A general overview of features and applications of PNAs (peptide nucleic acids).
Canepa B., Velasco S.
Chemistry today 2005
Peptide Nucleic Acids (PNAs) are synthetic mimics of DNA in which the sugar-phosphate backbone has been replaced by a pseudopeptide skeleton. These molecules bind to complementary DNA and RNA sequences with high affinity and specificity, forming complexes with extraordinary chemical and biological stability. First described in 1991, PNAs have received great attention due to their several favorable properties. The unique physico-chemical and biological characteristics of PNA, open up many important biological, diagnostic and therapeutics applications, not achievable with traditional oligonucleotides.